New Brain Nutrition Organizational Structure

Our New Brain Nutrition project is professionally organized into 10 different work groups, called Work Packages.  The following table is a brief description of how we are organized and what each work group is responsible for, from existing data research, to clinical trials, to dissemination of results, public policy implications, and ethics requirements and training.  We are staffed by highly experienced professionals, researchers, PhDs, MDs to bring this project to fruition by 2022.

Work Package Task
WP1 Research existing study data to generate new knowledge on mental health and brain nutrition
WP2 Nutritional interventions- clinical trials with diets and supplementation
WP3 Effects of physical activity and exercise in interaction with diet
WP4 Public health aspects, policy recommendations, and dissemination
WP5 Intestinal microbiota as a mechanistic link between nutrition/ lifestyle and mental health
WP6 Effects of nutrition, lifestyle, and microbiota on the brain
WP7 Epigenetic (non-genetic) modification profiles for mental health; comparing mouse model results with human results to confirm findings
WP8 Ethics and Training
WP9 Project management and implementation
WP10 Ethics requirements

Manuscripts to be Published

Work Package Manuscripts to be written
WP1
  1. Effects of dietary intake and lifestyle across lifespan stratified by sex and SES
  2. Effects of dietary intake during pregnancy on offspring impulsivity and compulsivity
  3. How lifestyle may enhance harmful/benefical effects of diet or cancel these out
  4. How genetic contributions to impulsivity and compulsivity depend on dietary intake and lifestyle using twin
  5. Offspring candidate gene pathways x maternal diet/lifestyle interactions during pregnancy on offspring
  6. Candidate gene pathways x diet/lifestyle interactions on impulsivity and compulsivity
  7. A genome-wide by environment interaction study (GWEIS) on impulsivity and compulsivity
WP2
  1. Effects of probiotics on symptoms of impulsivity, compulsivity and aggression
  2. Effects of Mediterranean diet on symptoms of impulsivity, compulsivity and aggression
  3. Effects of elimination diet on symptoms of impulsivity, compulsivity and aggression
  4. Effects of supplements on symptoms of impulsivity, compulsivity and aggression
  5. Predictors of clinical response to nutritional interventions
WP3
  1. Analysis of joint effects of physical activity and nutrition on impulsive symptoms
  2. Analysis of joint effects of physical activity and nutrition on compulsive symptoms
  3. Analysis of joint effects of physical activity and nutrition on resilient behavior
WP5
  1. Effect of dietary interventions on microbiome composition and its relation to impulsive/compulsive behavior
  2. Mediation effect of the microbiome composition and metabolism on brain-behavior relationship
  3. Effect of physical activity on the microbiome composition and its relation with behavior
  4. Effect of the interaction between the microbiome and host genome on behavior
  5. Predictive power of selected diet / exercise / inflammation biomarkers for behavior
WP6
  1. Effect of nutrition, lifestyle, and behaviors on the brain
  2. Effect of nutrition, lifestyle, microbiome, and behavior on the brain
  3. Cross-replication results in animal studies
  4. Effects of elimination diet on brain measures
  5. Effects of vitamin supplementation on brain measures
  6. Effects of physical activity on brain measures
WP7
  1. Epigenetically moderated candidate genes for behaviors in selected cohorts
  2. Validation of selected epigenetically modified candidate genes between human cohorts and mouse models
  3. Nutritional and exercise intervention-induced epigenetic modifications in mouse models
  4. Novel epigenetically regulated genes following nutrition and exercise intervention in human cohorts