Organizational Structure and Publications

The Eat2BeNice project funded by the EU is professionally organized into 10 different work groups, called Work Packages.  The following table is a brief description of how we are organized and what each work group is responsible for, from existing data research, to clinical trials, to dissemination of results, public policy implications, and ethics requirements and training.  We are staffed by highly experienced professionals, researchers, PhDs, MDs to bring this project to fruition by 2022.

Register for Updates

Get Research Updates WHEN they are published!

We will publish progress reports, videos, interviews, blogs as we go.  Get the Updates here.

Work Package Task
WP1 Research existing study data to generate new knowledge on mental health and brain nutrition

Manuscripts to be published:

  1. Effects of dietary intake and lifestyle across lifespan stratified by sex and SES
  2. Effects of dietary intake during pregnancy on offspring impulsivity and compulsivity
  3. How lifestyle may enhance harmful/benefical effects of diet or cancel these out
  4. How genetic contributions to impulsivity and compulsivity depend on dietary intake and lifestyle using twin
  5. Offspring candidate gene pathways x maternal diet/lifestyle interactions during pregnancy on offspring
  6. Candidate gene pathways x diet/lifestyle interactions on impulsivity and compulsivity
  7. A genome-wide by environment interaction study (GWEIS) on impulsivity and compulsivity
WP2 Nutritional interventions- clinical trials with diets and supplementation[1]

Manuscripts to be published

  1. Effects of probiotics on symptoms of impulsivity, compulsivity and aggression
  2. Effects of Mediterranean diet on symptoms of impulsivity, compulsivity and aggression
  3. Effects of elimination diet on symptoms of impulsivity, compulsivity and aggression
  4. Effects of supplements on symptoms of impulsivity, compulsivity and aggression
  5. Predictors of clinical response to nutritional interventions
WP3 Effects of physical activity and exercise in interaction with diet

Manuscripts to be published:

  1. Analysis of joint effects of physical activity and nutrition on impulsive symptoms
  2. Analysis of joint effects of physical activity and nutrition on compulsive symptoms
  3. Analysis of joint effects of physical activity and nutrition on resilient behavior
WP4 Public health aspects, policy recommendations, and dissemination
WP5 Intestinal microbiota as a mechanistic link between nutrition / lifestyle and mental health

Manuscripts to be published:

  1. Effect of dietary interventions on microbiome composition and its relation to impulsive/compulsive behavior
  2. Mediation effect of the microbiome composition and metabolism on brain-behavior relationship
  3. Effect of physical activity on the microbiome composition and its relation with behavior
  4. Effect of the interaction between the microbiome and host genome on behavior
  5. Predictive power of selected diet / exercise / inflammation biomarkers for behavior
WP6 Effects of nutrition, lifestyle, and microbiota on the brain

Manuscripts to be published:

  1. Effect of nutrition, lifestyle, and behaviors on the brain
  2. Effect of nutrition, lifestyle, microbiome, and behavior on the brain
  3. Cross-replication results in animal studies
  4. Effects of elimination diet on brain measures
  5. Effects of vitamin supplementation on brain measures
  6. Effects of physical activity on brain measures
WP7 Epigenetic (non-genetic) modification profiles for mental health; comparing mouse model results with human results to confirm findings

Manuscripts to be published:

  1. Epigenetically moderated candidate genes for behaviors in selected cohorts
  2. Validation of selected epigenetically modified candidate genes between human cohorts and mouse models
  3. Nutritional and exercise intervention-induced epigenetic modifications in mouse models
  4. Novel epigenetically regulated genes following nutrition and exercise intervention in human cohorts
WP8 Ethics and Training[2]
WP9 Project management and implementation
WP10 Ethics requirements

New Brain Nutrition Clinical Trials

As part of the Eat2BeNice Project, four clinical trials will be conducted.

[1] Work Package 2 (WP2) is responsible for designing and completing four clinical trials which will test the relationship between nutrition and mental health.  All trials are conducted by experts who are both clinicians and researchers.

[2]Trial design and implementation is overseen by an Ethics Board. The Board will implement an ethical review and monitoring process to ensure proper conduct of all partners over time.

Work Package 8 (WP8) will ensure that the highest standards for the scientific and medical ethical aspects of the proposed studies are set and met. The studies will be conducted in compliance with European Directive 86/609/EEC, the Recommendation 2007/526/65/EC, ICH Good Clinical Practice (GCP) and the legal regulations of the European Union, national legislations and local medical ethical committees, and the Federation of European Laboratory Animal Science Associations (FELASA) 2012 guidelines for the protection of animals used for scientific purposes (see also section 5.1 Ethics for more discussion of the ethics aspects of the Eat2beNICE programme). The Declaration of Helsinki in its latest accepted version will be adhered to. The responsible ethics committees and competent authorities will approve study protocols and substantial amendments before the start of the studies.

The four clinical trials are:

  1. To determine the short- and long-term effects of a personalized elimination diet (ED) versus a standardized diet according to WHO health guidelines.
  2. To determine the double-blind placebo controlled (10 weeks) and open label (10 weeks) effects of broadspectrum supplementation.
  3. To determine the double-blind placebo controlled (10 weeks) and open label (10 weeks) effects of probiotics.
  4. To determine the short- and long-term effects of an energy-restricted Mediterranean diet with physical activity promotion and behavioural treatment versus an unrestricted caloric Mediterranean diet.
Register for Updates

Get Research Updates WHEN they are published!

We will publish progress reports, videos, interviews, blogs as we go.  Get the Updates here.