The Few-Foods Diet Approach
It has been suggested that for a subgroup of children and adolescents with ADHD, symptoms may be the result of hypersensitivity to certain foods (1). To define whether or not food is a trigger for ADHD, children can undergo an individualised few-foods diet procedure. The procedure starts with a highly restrictive phase, in which the child eats only very few foods. If the child responds well (i.e., if ADHD symptoms subside or even disappear), foods are re-introduced one by one to find which foods are causing the ADHD symptoms. The few-foods diet approach has been criticized for being too restrictive, making adherence to the diet extremely difficult – if not impossible – especially for young people. Recently, the inventors of the few-foods diet approach put their methods to the test in clinical practice (2). In this blog post I will talk you through the results of their test, focussing on two important questions: was the few-foods diet approach feasible for children/adolescents and their parents, and, perhaps more importantly, did the diet work?

Vegetables, Rice and Meat
A total of fifty-seven Dutch children with ADHD or longstanding behavioural problems enrolled in the study. Approximately half of the children were taking psychostimulants. After an elaborate inventory of the children’s habitual eating patterns, the children started on a five-week diet consisting of lettuce, carrots, cauliflower, cabbage, beet, rice, meat and water, complemented with limited amounts of potatoes, fruits, wheat, butter, corn and honey. If behaviour did not improve within two weeks, the diet was further restricted to vegetables, rice and meat only. To support their children, parents were encouraged to adhere to the diet as well and to remove all non-allowed foods from the house. After five weeks of the diet, the next phases of the study were tailored individually. While some returned to their habitual diets (for instance, because the few-foods diet did not work), others attempted to cease stimulant treatment while maintaining the few-foods diet, and yet others proceed to the reintroduction phase.

How Feasible is the Few-Foods Diet for Children and Their Parents?
Ninety-one percent of the children (52 out of 57) completed the first five weeks of the few-foods diet. Five children could not adhere to the strict diet and dropped out. Of the 52 children who completed the first five weeks of the few-foods diet, 21 children (40%) followed the most restricted diet consisting of only vegetables, rice and meat. Thus, the vast majority of children and parents made it through the first five weeks of the few-foods diet, even when the diet consisted of only a narrow selection of vegetables, rice and meat. This is an impressive achievement on the side of the children, their parents and the professionals guiding the families.

A crucial next question is whether the children and parents were willing to take the new diet forward. Adhering to a diet for five weeks can be challenging, but adhering for much longer – up to one and a half years – is something entirely different. Of the 34 children for whom the diet seemed to work, 26 were willing to enter the reintroduction phase. Two children for whom the diet had only a small beneficial effect started the reintroduction phase as well. Of the 28 children who entered the reintroduction phase, 14 (50%) were still following the few-foods diet six months later and another three children had stopped participating in the study but intended to continue following the few-foods diet. Thus, approximately half of the children who intended to follow the few-foods diet and who benefited from it managed to adhere to the diet for at least six months, while the other half of the children did not manage.

Does the Few-Foods Fiet Work?
After five weeks, 34 out of 57 children (60%) responded well to the few-foods diet, meaning that they experienced substantially fewer or less severe symptoms of ADHD. This group included 12 children who were taking psychostimulants at the start of the study and were able to stop taking medication while on the few-foods diet. The group of responders also included at least six children who responded favourably according to the study criteria, but not to their parents’ expectation. Thus, we conclude that after five weeks, approximately half of the children benefited from adhering to the stringent few-foods diet.

A Few Things to Keep in Mind
The outcomes of the study seem favourable: the vast majority of families managed to adhere to the few-foods diet during the first five weeks, and approximately half of the children responded beneficially to the few-foods diet. In fact, in many cases, taking psychostimulants was no longer necessary. There are, however, a few things to keep in mind when interpreting these results.

First, it is likely that parents who participated in the study were biased towards a positive outcome. In other words: it is likely that parents, whose report of their child’s behaviour was the primary outcome in the study, consciously or unconsciously wanted the few-foods diet to work. The parents had invested in the few-foods diet. Not only had they spent time and effort into their child’s (and oftentimes their entire family’s) adhering to the diet, but they had also invested financially: most health insurance companies in the Netherlands do not cover the few-foods diet, thus most parents had had to pay for the dietary treatment.

Second, the study was not blinded: practitioners, parents and children inevitably knew that they were undergoing the few-foods diet. Although blinding in a few-foods diet study such as this one is impossible, the absence of blinding does increase the risk of a placebo effect. In other words, as before, there is a reasonable chance that the diet works because the children and/or parents want or expect it to work.

Third, there is no control group in the study. Normally, to establish the effect of treatment A, one compares it to the (known) effect treatment B and/or to a placebo treatment. As a result of the absence of a control group, we don’t know what exactly is causing the effect of the few-foods diet. The beneficial effect could result from the lack of allergens in the few-foods diet, but it could also result from the increased parental guidance required for the child’s adherence to the few-foods diet.

In a new study (TRACE) performed by members of the Eat2beNICE consortium, we attempt to address these concerns. For instance, some of the children participating in the new study are instructed to follow a generally healthy diet rather than the few-foods diet. Comparing the outcomes in this control group to the outcomes of the children who followed the few-foods diet tells us whether the beneficial effect of the strict few-foods diet is indeed attributable to this particular diet. More information about the new TRACE study can be found here.

Yay or Nay?
In conclusion: in a subgroup of children whose ADHD symptoms stem from an allergic reaction to food allergens, the few-foods diet may offer a viable treatment option. Although the treatment is effective after five weeks, many children and their families do not manage to adhere to the diet in the long-term. We note that part of the beneficial effect of the few-foods diet is likely not attributable to the diet itself, but rather to non-specific factors including bias and a placebo effect.

REFERENCES:

(1) Pelsser LM, Frankena K, Toorman J, Savelkoul HF, Pereira RR, Buitelaar JK. A randomised controlled trial into the effects of food on ADHD. Eur Child Adolesc Psychiatry (2009) 18:12–9. 10.1007/s00787-008-0695-7

(2) Pelsser L, Frankena K, Toorman J, and Rodrigues Pereira R (2020). Retrospective Outcome Monitoring of ADHD and Nutrition (ROMAN): The Effectiveness of the Few-Foods Diet in General Practice. Front Psychiatry. 11: 96. doi: 10.3389/fpsyt.2020.00096

About the author

Lizanne JS Schweren, PhD, is a postdoctoral research associate in the eat2beNICE project at the University Medical Center Groningen, the Netherlands. Her background is in long-term outcomes of stimulant treatment for ADHD, developmental psychiatry and neuroscience.

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About Lizanne Schweren, PhD

Lizanne JS Schweren, PhD, is a postdoctoral research associate in the eat2beNICE project at the University Medical Center Groningen, the Netherlands. Her background is in long-term outcomes of stimulant treatment for ADHD, developmental psychiatry and neuroscience.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 728018

New Brain Nutrition is a project and brand of Eat2BeNice, a consortium of 18 European University Hospitals throughout the continent.

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