The Department of Psychiatry, Psychosomatic Medicine and Psychotherapy at the University Hospital of Frankfurt (Head: Prof. Dr. A. Reif) is uniquely and ideally suited to carry out translational research in psychiatry. Key research questions revolve around developmental psychiatry (in close collaboration with the Department for Child and Adolescent Psychiatry; Head: Prof. Dr. C.M. Freitag, and as evidenced by the recent foundation of the German Center for Developmental Psychiatry D-ZEP), precision medicine approaches in psychiatry including biomarker discovery, and translational psychiatry with a focus on the pathophysiology of ADHD, bipolar disorder, and major depression. On the one hand, there is access to large patient samples, as the Department features >150 inpatient beds, room for 30 day-patients, and large outpatient facilities specialized for patients suffering from ADHD and affective disorders. Beyond treatment, as usual, there is an extensive and elaborate clinical research framework including early recognition of psychiatric disorders, cognitive remediation, long-term follow-up of patients including neuropsychological /-imaging examinations and ambulatory assessment as performed in two multicentre clinical trials.