READ IN AND FIND OUT!

On this page we show you all research publications of the Eat2beNICE consortium. These publications report on the research output of the project. For each publication we provide a summary or the publication’s abstract. If you want to read the full article, you can click on the link below the summary or abstract. For PDFs of our own press releases about progress within the Eat2beNICE project please go to DOWNLOADS. To receive our project newsletter please subscribe here!

Dominik P Kiser
By: Dominik P Kiser
On: 8 March 2019

Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice

Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the presynaptic compartment of inhibitory GABAergic synapses in the hippocampus and Cdh13 knockout mice show an increased inhibitory drive onto hippocampal CA1 pyramidal neurons, leading to a shift in excitatory/inhibitory balance. CDH13 is also moderating migration of serotonergic neurons in the dorsal raphe nucleus, establishing projections preferentially to the thalamus and cerebellum during brain development. Furthermore, CDH13 is upregulated by chronic stress as well as in depression, suggesting a role in early-life adaptation to stressful experience. Here, we therefore investigated the interaction between Cdh13 variation and neonatal maternal separation (MS) in mice

Dmitrii Pavlov
By: Dmitrii Pavlov
On: 2 March 2019

The effects of emotional stress on brain and behaviour in mice

Emotional stress is a form of stress evoked by processing negative mental experience rather than an organic or physical disturbance and is a frequent cause of neuropsychiatric pathologies, including depression. Susceptibility to emotional stress is commonly regarded as a human-specific trait that is challenging to model in other species. Recently, we showed that a 3-week-long exposure to ultrasound of unpredictable alternating frequencies within the ranges of 20-25 kHz and 25-45 kHz can induce depression-like characteristics in laboratory mice and rats.

Dr. Konstantin Mechler
By: Dr. Konstantin Mechler
On: 21 February 2019

Investigating the effects of micronutrients on impulsivity: the VANTASTIC study

Despite the popularity with consumers of using nutritional methods for the treatment of psychiatric illnesses, high quality evidence is missing. First studies assessing micronutrients for the treatment of impulsivity/ADHD have shown promising benefits. However, in the child/adolescent area, they have been mainly open- label, retrospective database analyses, case reports, or patient preference studies. Cross-disorder approaches and studies investigating long-term effects are missing. Thus, further research is required, in particular controlled studies with adolescents in larger samples.

Urmeli Joost
By: Urmeli Joost
On: 17 February 2019

The role of the TFAP2B gene in obesity and insulin resistance

The development of obesity has a large genetic component, and the gene encoding the transcription factor 2 beta (TFAP2B) has been identified as one of the responsible factors. We investigated the effect of TFAP2B intron 2 variable number tandem repeat (VNTR) genotype on obesity, insulin resistance and dietary intake from 15 to 33 years of age.

Niklas Kästner
By: Niklas Kästner
On: 4 February 2019

Brain serotonin deficiency affects female aggression in mice

The neurotransmitter serotonin plays a key role in the control of aggressive behaviour. While so far most studies have investigated variation in serotonin levels, a recently created tryptophan hydroxylase 2 (Tph2) knockout mouse model allows studying effects of complete brain serotonin deficiency. First studies revealed increased aggressiveness in homozygous Tph2 knockout mice in the context of a resident-intruder paradigm. Focussing on females, this study aimed to elucidate effects of serotonin deficiency on aggressive and non-aggressive social behaviours not in a test situation but a natural setting.

Dr. Maria Soler Artigas
By: Dr. Maria Soler Artigas
On: 4 January 2019

The genetic overlap between ADHD and cannabis use

Attention-deficit/hyperactivity disorder (ADHD) is a severely impairing neurodevelopmental disorder with a prevalence of 5% in children and adolescents and of 2.5% in adults. Comorbid conditions in ADHD play a key role in symptom progression, disorder course and outcome. ADHD is associated with a significantly increased risk for substance use, abuse and dependence. ADHD and cannabis use are partly determined by genetic factors; the heritability of ADHD is estimated at 70–80% and of cannabis use initiation at 40–48%.

Dr. Cristina Sánchez-Mora
By: Dr. Cristina Sánchez-Mora
On: 19 December 2018

Epigenetics of ADHD – how behaviors and environment can cause changes in the way genes work

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders in childhood and persists into adulthood in 40–65% of cases. Given the polygenic and heterogeneous architecture of the disorder and the limited overlap between genetic studies, there is a growing interest in epigenetic mechanisms, such as microRNAs, that modulate gene expression and may contribute to the phenotype. We attempted to clarify the role of microRNAs in ADHD at a molecular level through the first genome-wide integrative study of microRNA and mRNA profiles in peripheral blood mononuclear cells of medication-naive individuals with ADHD and healthy controls.

Núria Mallorquí-Bagué et al
By: Núria Mallorquí-Bagué et al
On: 31 October 2018

Type 2 diabetes linked to worse cognitive performance in elderly

This study aimed to specify the association between the presence of type 2 diabetes and cognitive decline in older individuals in a situation of overweight or obesity and high cardiovascular risk.

Arunima Roy
By: Arunima Roy
On: 30 April 2018

Interactions between family environment and genetics

Corticotrophin-releasing hormone receptor-1 gene (CRHR1) variants have been implicated in mental health. However, little is known of the effects of CRHR1 on long-term mental health and behavior in presence of environmental stressors. We assess the effects of CRHR1 variant (rs17689918)-by-environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors. We also determine effects of rs17689918-by-environment-by-sex interactions on the above-mentioned outcomes.

Charline Jansch
By: Charline Jansch
On: 30 April 2018

Cell model to study ADHD in vitro

Fibroblasts were isolated from a skin biopsy of a clinically diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying a duplication of SLC2A3, a gene encoding neuronal glucose transporter-3 (GLUT3).