On this page we show you all research publications of the Eat2beNICE consortium. These publications report on the research output of the project. For each publication we provide a summary or the publication’s abstract. If you want to read the full article, you can click on the link below the summary or abstract. For PDFs of our own press releases about progress within the Eat2beNICE project please go to DOWNLOADS. To receive our project newsletter please subscribe here!

Nina Roth Mota
By: Nina Roth Mota
On: 2 January 2020

Genetic links between dopamine, ADHD and obesity

Attention-Deficit/Hyperactivity Disorder (ADHD) and obesity are frequently comorbid, genetically correlated, and share brain substrates. The biological mechanisms driving this association are unclear, but candidate systems, like dopaminergic neurotransmission and circadian rhythm, have been suggested. Our aim was to identify the biological mechanisms underpinning the genetic link between ADHD and obesity measures and investigate associations of overlapping genes with brain volumes.

Katrin Tomson-Johanson
By: Katrin Tomson-Johanson
On: 2 December 2019

Low cholesterol levels in children predict impulsivity in young adulthood

Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.

Trevor Steward
By: Trevor Steward
On: 25 October 2019

Brain mechanisms of impulsive and compulsive behaviors in obesity

Impulsivity and compulsivity are multidimensional constructs that are increasingly considered determinants of obesity. Studies using functional magnetic resonance imaging (fMRI) have provided insight on how differences in brain response during tasks exploring facets of impulsivity and compulsivity relate to the ingestive behaviors that support the etiology and maintenance of obesity.

Jenny van Dongen
By: Jenny van Dongen
On: 15 October 2019

Epigenetics of adult ADHD

Previous studies have reported associations between attention-deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first epigenome-wide association study meta-analysis of adult attention-deficit/hyperactivity disorder symptoms, based on peripheral blood DNA methylation (Infinium HumanMethylation450K array) in three population-based adult cohorts.

Laura Pineda-Cirera
By: Laura Pineda-Cirera
On: 3 October 2019

Altered gene expression in ADHD: three new genes identified

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder caused by an interplay of genetic and environmental factors. Epigenetics is crucial to lasting changes in gene expression in the brain. Recent studies suggest a role for DNA methylation in ADHD. We explored the contribution to ADHD of allele-specific methylation (ASM), an epigenetic mechanism that involves SNPs correlating with differential levels of DNA methylation at CpG sites.

Trevor Steward
By: Trevor Steward
On: 27 September 2019

Brain mechanisms of risk-taking behaviour in obesity after a loss

Altered activity in decision-making neural circuitry may underlie the maladaptive food choices found in obesity. Here, we aimed to identify the brain regions purportedly underpinning risk-taking behavior in individuals with obesity. Twenty-three adult women with obesity and twenty-three healthy weight controls completed the Risky Gains Task during functional magnetic resonance imaging (fMRI).

Dr. Judit Cabana Dominguez
By: Dr. Judit Cabana Dominguez
On: 30 August 2019

Shared genetics between cocaine dependence and comorbid conditions

Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65–79%. Here we performed a meta-analysis of genome-wide association studies of cocaine dependence using four datasets from the dbGaP repository (2085 cases and 4293 controls, all of them selected by their European ancestry).

Trevor Steward
By: Trevor Steward
On: 20 August 2019

The neural mechanisms of emotion regulation impairment in women with obesity

Maladaptive emotion regulation contributes to overeating and impedes weight loss. Our study aimed to compare the voluntary downregulation of negative emotions by means of cognitive reappraisal in adult women with obesity (OB) and female healthy controls (HC) using a data-driven, multimodal magnetic resonance imaging (MRI) approach.

Laura Gisbert
By: Laura Gisbert
On: 6 June 2019

Genetic risks of emotional lability in adult ADHD

Emotional lability is strongly associated with Attention Deficit Hyperactivity Disorder (ADHD), represents a major source of impairment and predicts poor clinical outcome in ADHD. Given that no specific genes with a role in the co-occurrence of both conditions have been described, we conducted a GWAS of emotional lability in 563 adults with ADHD. Despite not reaching genome-wide significance, the results highlighted genes related with neurotransmission, cognitive function and a wide range of psychiatric disorders that have emotional lability as common clinical feature.

Magdalena T Weidner
By: Magdalena T Weidner
On: 10 May 2019

The interaction between serotonin genes and early life maternal seperation

Converging evidence suggests a role of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme of 5-HT synthesis in the brain, in modulating long-term, neurobiological effects of early-life adversity. Here, we aimed at further elucidating the molecular mechanisms underlying this interaction, and its consequences for socio-emotional behaviors, with a focus on anxiety and social interaction.