On this page we show you all research publications of the Eat2beNICE consortium. These publications report on the research output of the project. For each publication we provide a summary or the publication’s abstract. If you want to read the full article, you can click on the link below the summary or abstract. For PDFs of our own press releases about progress within the Eat2beNICE project please go to DOWNLOADS. To receive our project newsletter please subscribe here!

Aet O’Leary
By: Aet O’Leary
On: 10 August 2022

Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits

Common variation in the gene encoding the neuron-specific RNA splicing factor RNA Binding Fox-1 Homolog 1 (RBFOX1) has been identified as a risk factor for several psychiatric conditions, and rare genetic variants have been found causal for autism spectrum disorder (ASD).

Giulia Testa
By: Giulia Testa
On: 10 August 2022

Impulsive personality traits predict weight loss in individuals with type 2 diabetes after 3 years of lifestyle interventions

What was the goal of your research or experiment?

We investigated the influence of impulsive personality traits on the effectivity of a 3-year weight-loss program with a Mediterranean diet. We conducted this intervention trial with elderly individuals with type 2 diabetes. We hypothesized that people who are more impulsive will have more trouble to control their weight and blood glucose levels over the duration of the diet intervention.

Carlos Gómez-Martínez
By: Carlos Gómez-Martínez
On: 8 August 2022

Impulsivity is longitudinally associated with healthy and unhealthy dietary patterns in individuals with overweight or obesity and metabolic syndrome within the framework of the PREDIMED-Plus trial

Few studies have analyzed the associations between impulsivity and dietary patterns. Some of them have shown a cross-sectional inverse relationship between impulsivity and healthy diet scores, whereas others reported a positive association with unhealthy dietary assessments. We aimed to examine longitudinal associations of impulsivity trait with adherence to healthy and unhealthy dietary patterns in older participants at high risk of cardiovascular disease over 3 years of follow-up.

Dr. Margus Kanarik
By: Dr. Margus Kanarik
On: 1 August 2022

ADHD co-morbidities: A review of implication of gene × environment effects with dopamine-related genes

ADHD is a major burden in adulthood, where co-morbid conditions such as depression, substance use disorder and obesity often dominate the clinical picture. ADHD has substantial shared heritability with other mental disorders, contributing to comorbidity. However, environmental risk factors exist but their interaction with genetic makeup, especially in relation to comorbid disorders, remains elusive. This review for the first time summarizes present knowledge on gene x environment (GxE) interactions regarding the dopamine system.

Jiaqi Ni
By: Jiaqi Ni
On: 1 August 2022

The relationship between dairy consumption and cognitive health in elderly individuals

What was the goal of your research or experiment?

Good cognitive health provides us with the ability to clearly think, learn and remember. These abilities are required to adequately perform daily activities. For elderly individuals, they are a major factor to ensure good quality of life and preserve independence. As the population ages, the increasing global prevalence of cognitive impairment, including dementia, is a growing public health concern. Faster rates of cognitive decline are likely to result in earlier onset of cognitive impairment and dementia. To date, there are still no effective treatments available to cure cognitive disorders or slow the rate of cognitive decline. Therefore, prevention strategies targeting modifiable risk factors, such as dietary intake and eating habits, are a promising approach.

Laura Domingo-Rodriguez
By: Laura Domingo-Rodriguez
On: 30 June 2022

Differential expression of miR-1249-3p and miR-34b-5p between vulnerable and resilient phenotypes of cocaine addiction

Cocaine addiction is a complex brain disorder involving long-term alterations that lead to loss of control over drug seeking. The transition from recreational use to pathological consumption is different in each individual, depending on the interaction between environmental and genetic factors. Epigenetic mechanisms are ideal candidates to study psychiatric disorders triggered by these interactions, maintaining persistent malfunctions in specific brain regions.

Ester Antón-Galindo
By: Ester Antón-Galindo
On: 2 May 2022

Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish

Genetic variants in YWHAZ contribute to psychiatric disorders such as autism spectrum disorder and schizophrenia, and have been related to an impaired neurodevelopment in humans and mice. Here, we have used zebrafish to investigate the mechanisms by which YWHAZ contributes to neurodevelopmental disorders.

Dr. Fernando Fernández-Aranda
By: Dr. Fernando Fernández-Aranda
On: 28 April 2022

The role of neurotrophin genes in gambling disorder

What was the goal of your research or experiment?

Gambling Disorder is caused by a complex interplay of biological, psychological and social factors. Earlier research has identified a possible role of neurotrophic factors in addiction-related disorders. Therefore, these factors could be a promising biomarker for Gambling Disorder. Neurotrophic factors are small proteins that play an important role in the growth, survival and development of brain cells. The main goal of this study was to explore the association between neurotrophic genes and Gambling Disorder. We hypothesized that certain variations in neurotrophin genes could constitute potential biological risk factors for this disorder

Alejandra García-Blanco
By: Alejandra García-Blanco
On: 29 March 2022

miRNA signatures associated with vulnerability to food addiction in mice and humans

Food addiction is characterized by a loss of behavioral control over food intake and is associated with obesity and other eating disorders. The mechanisms underlying this behavioral disorder are largely unknown. We aimed to investigate the changes in miRNA expression promoted by food addiction in animals and humans and their involvement in the mechanisms underlying the behavioral hallmarks of this disorder.

Dr. Fernando Fernández-Aranda
By: Dr. Fernando Fernández-Aranda
On: 29 March 2022

Binge eating disorder

Binge eating disorder (BED) is characterized by regular binge eating episodes
during which individuals ingest comparably large amounts of food and experience
loss of control over their eating behaviour. The worldwide prevalence of BED for the years 2018–2020 is estimated to be 0.6–1.8% in adult women and 0.3–0.7% in adult men. BED is commonly associated with obesity and with somatic and mental health comorbidities. People with BED experience considerable burden and impairments in quality of life, and, at the same time, BED often goes undetected and untreated. The aetiology of BED is complex, including genetic and environmental factors as well as neuroendocrinological and neurobiological contributions. Neurobiological findings highlight impairments in reward processing, inhibitory control and emotion regulation in people with BED, and these neurobiological domains are targets for emerging treatment approaches.